Inflammasomes in liver diseases
نویسندگان
چکیده
منابع مشابه
Inflammasomes in cardiovascular diseases.
NOD-like receptors (NLRs) constitute a recently identified family of macromolecules that participate in regulation of innate immune responses. To date, 23 members of the NLR family are identified in humans. Diverse NLRs are stimulated by a broad range of pathogen- or danger-associated molecular patterns, and collectively function as intracellular pattern recognition receptors (PRRs). The most s...
متن کاملInflammasomes in the Pathophysiology of Kidney Diseases
Background: The inflammasome is a complex of proteins in the cytoplasm that consists of three main components: a sensor protein (receptor), an adapter protein and caspase-1. Inflammasomes are the critical components of innate immunity and have been gradually recognized as a critical mediator in various autoimmune diseases; also, their role in chronic kidney disease and acute kidney injury has b...
متن کاملInflammasomes in the Pathophysiology of Kidney Diseases
Background: The inflammasome is a complex of proteins in the cytoplasm that consists of three main components: a sensor protein (receptor), an adapter protein and caspase-1. Inflammasomes are the critical components of innate immunity and have been gradually recognized as a critical mediator in various autoimmune diseases; also, their role in chronic kidney disease and acute kidney injury has b...
متن کاملInflammasomes in the Pathophysiology of Kidney Diseases.
BACKGROUND The inflammasome is a complex of proteins in the cytoplasm that consists of three main components: a sensor protein (receptor), an adapter protein and caspase-1. Inflammasomes are the critical components of innate immunity and have been gradually recognized as a critical mediator in various autoimmune diseases; also, their role in chronic kidney disease and acute kidney injury has be...
متن کاملInflammasomes in non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is a leading liver disorder in the world. Inflammation is one of the most important pathological events during the development of NAFLD and also represents the hallmark between simple steatosis and non-alcoholic steatohepatitis (NASH). Inflammasomes are novel protein complex platforms assembled in response to pattern-associated molecular patterns (PAMPs...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2012
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2012.03.035